name status hap1_main hap2_main hap1_cand hap2_cand hap1_score hap2_score dip_score phenotype dip_sv hap1_sv hap2_sv ssr dip_cand hap1_main_core hap2_main_core hap1_main_tag hap2_main_tag hap1_af_mean_gene hap2_af_mean_gene hap1_af_mean_main hap2_af_mean_main 363110 g *17 *29 *17,*2,*39,*34 *29,*2,*39,*34,*107 0.5 0.5 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2139.5 *29,*17,*2,*39,*34,*107 <42525772:G>A:27/55:0.49:missense_variant:high_impact:T107I> <42522613:C>G:35/35:1.00:missense_variant:low_impact:S486T>,<42523610:C>T:25/54:0.46:missense_variant:moderate_impact:V338M>,<42523943:G>A:44/44:1.00:missense_variant:low_impact:R296C>,<42525134:C>T:27/54:0.50:missense_variant:moderate_impact:V136M> <42522613:C>G:35/35:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:44/44:1.00:missense_variant:low_impact:R296C> . 0.49 0.51 0.49 0.48 363111 g *1 *4 *1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2454.6 *4,*10,*39 . <42524947:C>T:21/47:0.45:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:18/44:0.41:missense_variant:high_impact:P34S> 0.55 0.45 . 0.45 363112 ng . . *5 *36x3,*5,*10,*39 . . . . cnv0,gc_e9_3 . . 5229.9 *36x3,*5,*10,*39 . <42525132:C>G:72/105:0.69:synonymous_variant:low_impact:V136#>,<42525952:A>C:26/36:0.72:intron_variant:low_impact:no_effect>,<42526484:C>A:51/74:0.69:intron_variant:low_impact:no_effect>,<42526694:G>A:58/81:0.72:missense_variant:high_impact:P34S>,<42527793:C>T:65/79:0.82:upstream_gene_variant:low_impact:no_effect> . . 0.37 0.63 . 0.73 363113 g *1 *36+*10 *1 *36+*10,*39 1.0 0.25 1.25 normal_metabolizer no_sv,gc_e9 no_sv gc_e9 3942.5 *36,*83,*10,*39 . <42525132:C>G:55/83:0.66:synonymous_variant:low_impact:V136#>,<42525952:A>C:17/31:0.55:intron_variant:low_impact:no_effect>,<42526484:C>A:32/61:0.52:intron_variant:low_impact:no_effect>,<42526694:G>A:49/71:0.69:missense_variant:high_impact:P34S>,<42527793:C>T:41/63:0.65:upstream_gene_variant:low_impact:no_effect> . . 0.45 0.55 . 0.62 363114 g *1 *35 *1 *35,*2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 2571.9 *35,*2,*39,*34 . <42522613:C>G:42/91:0.46:missense_variant:low_impact:S486T>,<42523943:G>A:56/120:0.47:missense_variant:low_impact:R296C>,<42525132:C>G:66/129:0.51:synonymous_variant:low_impact:V136#>,<42526763:C>T:51/112:0.46:missense_variant:low_impact:V11M> . . 0.51 0.49 . 0.47 363115 g *36+*10 *36+*10 *36+*10 *36+*10 0.25 0.25 0.5 intermediate_metabolizer gc_e9,gc_e9 gc_e9 gc_e9 3294.8 *36,*83,*10,*39 <42525132:C>G:74/74:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:25/38:0.66:intron_variant:low_impact:no_effect>,<42526484:C>A:55/74:0.74:intron_variant:low_impact:no_effect>,<42526694:G>A:59/82:0.72:missense_variant:high_impact:P34S>,<42527793:C>T:50/70:0.71:upstream_gene_variant:low_impact:no_effect> <42525132:C>G:74/74:1.00:synonymous_variant:low_impact:V136#> . . 0.60 0.40 0.71 . 363116 g *1 *1 *1 *1 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 2056.8 *1 . . . . 0.54 0.46 . . 363117 g *17 *29 *17,*2,*39,*34 *29,*2,*39,*34,*107 0.5 0.5 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 3146.2 *29,*17,*2,*39,*34,*107 <42525772:G>A:12/30:0.40:missense_variant:high_impact:T107I> <42522613:C>G:42/42:1.00:missense_variant:low_impact:S486T>,<42523610:C>T:26/48:0.54:missense_variant:moderate_impact:V338M>,<42523943:G>A:30/30:1.00:missense_variant:low_impact:R296C>,<42525134:C>T:13/37:0.35:missense_variant:moderate_impact:V136M> <42522613:C>G:42/42:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:30/30:1.00:missense_variant:low_impact:R296C> . 0.45 0.55 0.40 0.45 363118 g *1 *36+*10 *1 *36+*10,*39 1.0 0.25 1.25 normal_metabolizer no_sv,gc_e9 no_sv gc_e9 4009.9 *36,*83,*10,*39 . <42525132:C>G:58/79:0.73:synonymous_variant:low_impact:V136#>,<42525952:A>C:28/33:0.85:intron_variant:low_impact:no_effect>,<42526484:C>A:49/70:0.70:intron_variant:low_impact:no_effect>,<42526694:G>A:45/63:0.71:missense_variant:high_impact:P34S>,<42527793:C>T:46/75:0.61:upstream_gene_variant:low_impact:no_effect> . . 0.34 0.66 . 0.72 363119 g *1 *17 *1 *17,*2,*39,*34 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 2538.9 *17,*2,*39,*34 . <42525772:G>A:22/38:0.58:missense_variant:high_impact:T107I> . <42522613:C>G:17/25:0.68:missense_variant:low_impact:S486T>,<42523943:G>A:29/50:0.58:missense_variant:low_impact:R296C> 0.51 0.49 . 0.58 363120 g *4 *4 *4,*10,*39 *4,*10,*39 0.0 0.0 0.0 poor_metabolizer no_sv,no_sv no_sv no_sv 2248.7 *4,*10,*39 <42524947:C>T:43/43:1.00:splice_acceptor_variant:high_impact:splicing_defect> <42524947:C>T:43/43:1.00:splice_acceptor_variant:high_impact:splicing_defect> <42526694:G>A:42/42:1.00:missense_variant:high_impact:P34S> <42526694:G>A:42/42:1.00:missense_variant:high_impact:P34S> 0.41 0.59 . . 363121 g *1 *36+*10 *1 *36+*10,*39 1.0 0.25 1.25 normal_metabolizer no_sv,gc_e9 no_sv gc_e9 5401.4 *36,*83,*10,*39 . <42525132:C>G:49/79:0.62:synonymous_variant:low_impact:V136#>,<42525952:A>C:16/25:0.64:intron_variant:low_impact:no_effect>,<42526484:C>A:36/57:0.63:intron_variant:low_impact:no_effect>,<42526694:G>A:66/92:0.72:missense_variant:high_impact:P34S>,<42527793:C>T:51/81:0.63:upstream_gene_variant:low_impact:no_effect> . . 0.43 0.57 . 0.65 363122 g *2 *2 *2,*39,*34 *2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1750.2 *2,*39,*34 <42522613:C>G:36/36:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:38/38:1.00:missense_variant:low_impact:R296C> <42522613:C>G:36/36:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:38/38:1.00:missense_variant:low_impact:R296C> . . . . . . 363123 g *2 *4x2 *2,*39,*34 *4x2,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,cnv2 no_sv cnv2 3149.7 *4,*10,*65,*2,*39,*34 <42522613:C>G:49/49:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:26/97:0.27:missense_variant:low_impact:R296C> <42524947:C>T:68/91:0.75:splice_acceptor_variant:high_impact:splicing_defect> . . 0.33 0.67 0.27 0.75 363124 g *1 *4 *1 *4,*10,*39,*127 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 3293.1 *4,*10,*39,*127 . <42524947:C>T:17/37:0.46:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:21/38:0.55:missense_variant:high_impact:P34S> 0.59 0.41 . 0.46 363125 g *2 *35 *2,*39,*34 *35,*2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 2392.3 *35,*2,*39,*34 <42522613:C>G:42/42:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:40/40:1.00:missense_variant:low_impact:R296C> <42522613:C>G:42/42:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:40/40:1.00:missense_variant:low_impact:R296C>,<42525132:C>G:39/39:1.00:synonymous_variant:low_impact:V136#>,<42526763:C>T:32/49:0.65:missense_variant:low_impact:V11M> . . 0.35 0.65 . 0.65 363126 g *1 *1 *1 *1 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 3627.1 *1 . . . . 0.51 0.49 . . 363127 g *S1+*1 *4 *S1+*1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,gc_i1e9 gc_i1e9 no_sv 2754.4 *S1,*4,*10,*39 . <42524947:C>T:20/53:0.38:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:72/89:0.81:missense_variant:high_impact:P34S> 0.51 0.49 . 0.38 363128 g *1 *6 *1 *6 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1476.4 *6 . <42525085:CA>C:28/54:0.52:frameshift_variant:high_impact:frameshift> . <42524817:C>T:22/78:0.28:missense_variant:moderate_impact:G212E> 0.58 0.42 . 0.52 363129 g *4x2 *41 *4x2,*10,*39 *41,*2,*39,*34 0.0 0.5 0.5 intermediate_metabolizer no_sv,cnv2 cnv2 no_sv 3483.3 *69,*4,*10,*41,*65,*2,*39,*34 <42524947:C>T:63/92:0.68:splice_acceptor_variant:high_impact:splicing_defect> <42523805:C>T:25/89:0.28:intron_variant:high_impact:splicing_defect> . <42522613:C>G:54/54:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:27/92:0.29:missense_variant:low_impact:R296C> 0.64 0.36 0.68 0.28 363130 g *2x2 *4 *2x2,*39,*34 *4,*10,*39 2.0 0.0 2.0 normal_metabolizer no_sv,cnv2 cnv2 no_sv 1998.2 *4,*10,*2,*39,*34 <42522613:C>G:56/56:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:46/74:0.62:missense_variant:low_impact:R296C> <42524947:C>T:34/71:0.48:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:14/57:0.25:missense_variant:high_impact:P34S> 0.67 0.33 0.62 0.48 363131 g *9 *35 *9 *35,*2,*39,*34 0.5 1.0 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 3179.6 *9,*35,*2,*39,*34 <42524175:CCTT>C:25/50:0.50:inframe_deletion:moderate_impact:K281del> <42522613:C>G:31/53:0.58:missense_variant:low_impact:S486T>,<42523943:G>A:27/51:0.53:missense_variant:low_impact:R296C>,<42525132:C>G:15/36:0.42:synonymous_variant:low_impact:V136#>,<42526763:C>T:17/40:0.42:missense_variant:low_impact:V11M> . . 0.51 0.49 0.50 0.49 363132 g *1 *41 *1 *41,*2,*39,*34 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 1872.8 *41,*2,*39,*34 . <42523805:C>T:23/40:0.57:intron_variant:high_impact:splicing_defect> . <42522613:C>G:20/44:0.45:missense_variant:low_impact:S486T>,<42523943:G>A:27/49:0.55:missense_variant:low_impact:R296C> 0.52 0.48 . 0.57 363133 g *1 *21 *1 *21,*121,*2,*39,*34 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2805.7 *21,*121,*2,*39,*34 . <42524213:C>CG:22/48:0.46:frameshift_variant:high_impact:frameshift> . <42522613:C>G:23/53:0.43:missense_variant:low_impact:S486T>,<42523943:G>A:35/74:0.47:missense_variant:low_impact:R296C>,<42525132:C>G:29/56:0.52:synonymous_variant:low_impact:V136#>,<42526580:C>G:21/52:0.40:intron_variant:low_impact:no_effect>,<42528382:G>C:22/35:0.63:upstream_gene_variant:low_impact:no_effect> 0.59 0.41 . 0.46 363134 g *1 *4 *1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1612.1 *4,*10,*39 . <42524947:C>T:20/46:0.43:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:27/53:0.51:missense_variant:high_impact:P34S> 0.54 0.45 . 0.43 363135 g *3 *121 *3 *121,*2,*39,*34 0.0 unknown unknown unknown no_sv,no_sv no_sv no_sv 2520 *3,*121,*2,*39,*34 <42524243:CT>C:16/25:0.64:frameshift_variant:high_impact:frameshift> <42522613:C>G:19/43:0.44:missense_variant:low_impact:S486T>,<42523943:G>A:25/48:0.52:missense_variant:low_impact:R296C>,<42525038:A>C:5/36:0.14:missense_variant:moderate_impact:S168A>,<42525039:G>T:5/36:0.14:missense_variant:moderate_impact:H167Q>,<42525044:T>C:5/37:0.14:missense_variant:moderate_impact:N166D> . . 0.53 0.47 0.64 0.28 363136 g *S1+*1 *5 *S1+*1 *5 1.0 0.0 1.0 intermediate_metabolizer cnv0,gc_i1e9 gc_i1e9 cnv0 2923.6 *5,*S1,*4,*10,*39 . . . . 0.69 0.31 . . 363137 g *5 *41 *5,*41,*121,*2,*39,*34 *41,*2,*39,*34 0.0 0.5 0.5 intermediate_metabolizer no_sv,cnv0 cnv0 no_sv 2250.6 *5,*41,*121,*2,*39,*34 . <42523805:C>T:17/17:1.00:intron_variant:high_impact:splicing_defect> . <42522613:C>G:20/20:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:25/25:1.00:missense_variant:low_impact:R296C> 0.18 0.82 . . 363138 g *2 *41 *2,*39,*34 *41,*2,*39,*34 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 1448.2 *41,*2,*39,*34 <42522613:C>G:36/36:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:46/46:1.00:missense_variant:low_impact:R296C> <42523805:C>T:31/59:0.53:intron_variant:high_impact:splicing_defect> . <42522613:C>G:36/36:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:46/46:1.00:missense_variant:low_impact:R296C> 0.47 0.53 . 0.53 363139 g *3 *121 *3 *121,*2,*39,*34 0.0 unknown unknown unknown no_sv,no_sv no_sv no_sv 2325.5 *3,*121,*2,*39,*34 <42524243:CT>C:17/38:0.45:frameshift_variant:high_impact:frameshift> <42522613:C>G:21/41:0.51:missense_variant:low_impact:S486T>,<42523943:G>A:26/56:0.46:missense_variant:low_impact:R296C>,<42525038:A>C:5/53:0.09:missense_variant:moderate_impact:S168A>,<42525039:G>T:5/53:0.09:missense_variant:moderate_impact:H167Q>,<42525044:T>C:5/51:0.10:missense_variant:moderate_impact:N166D> . . 0.50 0.50 0.45 0.25 363140 g *1 *15 *1 *15,*41,*2,*39,*34 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 889.9 *15,*41,*2,*39,*34 . <42526656:C>CA:30/55:0.55:frameshift_variant:high_impact:frameshift> . <42526562:C>G:26/58:0.45:intron_variant:low_impact:no_effect>,<42526571:G>C:28/65:0.43:intron_variant:low_impact:no_effect>,<42526573:G>T:28/68:0.41:intron_variant:low_impact:no_effect>,<42526580:C>G:26/62:0.42:intron_variant:low_impact:no_effect> 0.50 0.50 . 0.55 363141 g *1 *2 *1 *2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 4254.4 *2,*39,*34 . <42522613:C>G:40/79:0.51:missense_variant:low_impact:S486T>,<42523943:G>A:43/75:0.57:missense_variant:low_impact:R296C> . . 0.50 0.50 . 0.54 363142 g *1 *41 *1 *41,*2,*39,*34 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 2003.6 *41,*2,*39,*34 . <42523805:C>T:24/48:0.50:intron_variant:high_impact:splicing_defect> . <42522613:C>G:31/63:0.49:missense_variant:low_impact:S486T>,<42523943:G>A:34/56:0.61:missense_variant:low_impact:R296C> 0.51 0.49 . 0.50 363143 g *1 *5 *1 *5 1.0 0.0 1.0 intermediate_metabolizer no_sv,cnv0 no_sv cnv0 2066.4 *5 . . . . 0.48 0.52 . . 363144 g *S1+*1 *4 *S1+*1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,gc_i1e9 gc_i1e9 no_sv 3739.5 *S1,*4,*10,*39 . <42524947:C>T:38/71:0.54:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:59/77:0.77:missense_variant:high_impact:P34S> 0.49 0.51 . 0.54 363145 g *1 *2 *1 *2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1872 *2,*39,*34 . <42522613:C>G:33/60:0.55:missense_variant:low_impact:S486T>,<42523943:G>A:21/50:0.42:missense_variant:low_impact:R296C> . . 0.54 0.46 . 0.48 363146 g *5 *122 *5 *122 0.0 unknown unknown unknown no_sv,cnv0 cnv0 no_sv 1710.3 *5,*122 . <42523514:C>T:5/27:0.19:missense_variant:moderate_impact:V370I> . . 0.60 0.40 . 0.19 363147 g *36+*10 *36+*10 *36+*10 *36+*10 0.25 0.25 0.5 intermediate_metabolizer gc_e9,gc_e9 gc_e9 gc_e9 5965.5 *36,*83,*10,*39 <42525132:C>G:73/73:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:48/48:1.00:intron_variant:low_impact:no_effect>,<42526484:C>A:43/43:1.00:intron_variant:low_impact:no_effect>,<42526694:G>A:89/89:1.00:missense_variant:high_impact:P34S>,<42527793:C>T:108/108:1.00:upstream_gene_variant:low_impact:no_effect> <42525132:C>G:73/73:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:48/48:1.00:intron_variant:low_impact:no_effect>,<42526484:C>A:43/43:1.00:intron_variant:low_impact:no_effect>,<42526694:G>A:89/89:1.00:missense_variant:high_impact:P34S>,<42527793:C>T:108/108:1.00:upstream_gene_variant:low_impact:no_effect> . . . . . . 363148 g *1 *122 *1 *122 1.0 unknown unknown unknown no_sv,no_sv no_sv no_sv 2168.8 *122 . <42523514:C>T:8/81:0.10:missense_variant:moderate_impact:V370I> . . 0.66 0.34 . 0.10 363149 g *1 *4 *1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2702.2 *4,*10,*39 . <42524947:C>T:17/36:0.47:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:26/51:0.51:missense_variant:high_impact:P34S> 0.64 0.36 . 0.47 363150 g *1 *9 *1 *9,*127 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 1934.7 *9,*127 . <42524175:CCTT>C:27/55:0.49:inframe_deletion:moderate_impact:K281del> . . 0.58 0.42 . 0.49 363151 g *2 *41x3 *2,*39,*34 *41x3,*2,*39,*34 1.0 1.5 2.5 ultrarapid_metabolizer no_sv,cnv3 no_sv cnv3 4696.2 *41,*2,*39,*34 <42522613:C>G:50/50:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:53/53:1.00:missense_variant:low_impact:R296C> <42523805:C>T:88/128:0.69:intron_variant:high_impact:splicing_defect> . . 0.31 0.69 . 0.69 363152 g *5 *17 *5,*17,*2,*39,*34 *17,*2,*39,*34 0.0 0.5 0.5 intermediate_metabolizer no_sv,cnv0 cnv0 no_sv 2235.6 *5,*17,*2,*39,*34 . <42525772:G>A:17/17:1.00:missense_variant:high_impact:T107I> . <42522613:C>G:16/16:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:34/34:1.00:missense_variant:low_impact:R296C> . . . . 363153 g *1 *6 *1 *6 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 3678.8 *6 . <42525085:CA>C:23/45:0.51:frameshift_variant:high_impact:frameshift> . <42524817:C>T:15/60:0.25:missense_variant:moderate_impact:G212E> 0.37 0.63 . 0.51 363154 g *121 *122 *121,*2,*39,*34 *122 unknown unknown unknown unknown no_sv,no_sv no_sv no_sv 1625.3 *121,*2,*39,*34,*122 <42522613:C>G:27/53:0.51:missense_variant:low_impact:S486T>,<42523943:G>A:23/51:0.45:missense_variant:low_impact:R296C>,<42525038:A>C:7/53:0.13:missense_variant:moderate_impact:S168A>,<42525039:G>T:7/54:0.13:missense_variant:moderate_impact:H167Q>,<42525044:T>C:6/54:0.11:missense_variant:moderate_impact:N166D> <42523514:C>T:5/58:0.09:missense_variant:moderate_impact:V370I> . . 0.49 0.51 0.27 0.09 363155 g *1 *9 *1 *9 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 1695 *9 . <42524175:CCTT>C:26/53:0.49:inframe_deletion:moderate_impact:K281del> . . 0.51 0.49 . 0.49 363156 g *1 *121 *1 *121,*35,*2,*39,*34 1.0 unknown unknown unknown no_sv,no_sv no_sv no_sv 2449.9 *121,*35,*2,*39,*34 . <42522613:C>G:26/48:0.54:missense_variant:low_impact:S486T>,<42523943:G>A:12/32:0.38:missense_variant:low_impact:R296C>,<42525038:A>C:6/46:0.13:missense_variant:moderate_impact:S168A>,<42525039:G>T:6/46:0.13:missense_variant:moderate_impact:H167Q>,<42525044:T>C:6/44:0.14:missense_variant:moderate_impact:N166D> . . 0.54 0.46 . 0.26 363157 g *S1+*1 *4 *S1+*1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,gc_i1e9 gc_i1e9 no_sv 3195.2 *S1,*4,*10,*39 . <42524947:C>T:26/59:0.44:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:48/68:0.71:missense_variant:high_impact:P34S> 0.46 0.54 . 0.44 363158 g *1 *1 *1 *1 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 2575.6 *1 . . . . 0.49 0.51 . . 363159 g *1 *4 *1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2573.3 *4,*10,*39 . <42524947:C>T:22/50:0.44:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:13/38:0.34:missense_variant:high_impact:P34S> 0.62 0.38 . 0.44 363160 g *10 *36+*10 *10,*39 *36+*10,*39 0.25 0.25 0.5 intermediate_metabolizer no_sv,gc_e9 no_sv gc_e9 3219.2 *36,*83,*10,*39 <42526694:G>A:77/77:1.00:missense_variant:high_impact:P34S> <42525132:C>G:71/71:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:26/26:1.00:intron_variant:low_impact:no_effect>,<42526484:C>A:47/47:1.00:intron_variant:low_impact:no_effect>,<42526694:G>A:77/77:1.00:missense_variant:high_impact:P34S>,<42527793:C>T:79/79:1.00:upstream_gene_variant:low_impact:no_effect> . . . . . . 363161 g *S1+*1 *4 *S1+*1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,gc_i1e9 gc_i1e9 no_sv 3338 *S1,*4,*10,*39 . <42524947:C>T:36/83:0.43:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:73/101:0.72:missense_variant:high_impact:P34S> 0.48 0.52 . 0.43 363162 g *4 *5 *4,*10,*39 *5,*4,*10,*39 0.0 0.0 0.0 poor_metabolizer no_sv,cnv0 no_sv cnv0 1478 *5,*4,*10,*39 <42524947:C>T:26/27:0.96:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:28/28:1.00:missense_variant:high_impact:P34S> . 0.42 0.58 . . 363163 g *2 *5 *2,*39,*34 *5,*2,*39,*34,*122 1.0 0.0 1.0 intermediate_metabolizer no_sv,cnv0 no_sv cnv0 1847.3 *5,*2,*39,*34,*122 <42522613:C>G:26/26:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:21/21:1.00:missense_variant:low_impact:R296C> . . . 0.89 0.11 . . 363164 g *1 *4 *1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1943.3 *4,*10,*39 . <42524947:C>T:23/53:0.43:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:17/33:0.52:missense_variant:high_impact:P34S> 0.57 0.43 . 0.43 363165 g *4 *35 *4,*10,*39 *35,*2,*39,*34 0.0 1.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1576.3 *4,*10,*65,*35,*2,*39,*34 <42524947:C>T:20/50:0.40:splice_acceptor_variant:high_impact:splicing_defect> <42522613:C>G:37/37:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:30/58:0.52:missense_variant:low_impact:R296C>,<42525132:C>G:55/55:1.00:synonymous_variant:low_impact:V136#>,<42526763:C>T:28/50:0.56:missense_variant:low_impact:V11M> <42526694:G>A:30/53:0.57:missense_variant:high_impact:P34S> . 0.51 0.49 0.40 0.54 363166 g *2x2 *4x2 *2x2,*39,*34 *4x2,*10,*39 2.0 0.0 2.0 normal_metabolizer no_sv,cnv3 cnv2 cnv2 3109.6 *4,*10,*65,*2,*39,*34 <42522613:C>G:54/54:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:58/139:0.42:missense_variant:low_impact:R296C> <42524947:C>T:57/115:0.50:splice_acceptor_variant:high_impact:splicing_defect> . . 0.50 0.50 0.42 0.50 363167 g *2 *4 *2,*39,*34 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2124.3 *4,*10,*65,*2,*39,*34 <42522613:C>G:39/39:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:21/42:0.50:missense_variant:low_impact:R296C> <42524947:C>T:17/42:0.40:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:23/43:0.53:missense_variant:high_impact:P34S> 0.52 0.48 0.50 0.40 363168 g *2 *36+*10 *2,*39,*34 *36+*10,*39 1.0 0.25 1.25 normal_metabolizer no_sv,gc_e9 no_sv gc_e9 1463.9 *36,*83,*10,*65,*2,*39,*34 <42522613:C>G:41/41:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:29/98:0.30:missense_variant:low_impact:R296C> <42525132:C>G:69/69:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:42/42:1.00:intron_variant:low_impact:no_effect>,<42526484:C>A:42/42:1.00:intron_variant:low_impact:no_effect>,<42526694:G>A:49/75:0.65:missense_variant:high_impact:P34S>,<42527793:C>T:49/80:0.61:upstream_gene_variant:low_impact:no_effect> . . 0.32 0.68 0.30 0.63 363169 g *1x2 *2x2 *1x2 *2x2,*39,*34 2.0 2.0 4.0 ultrarapid_metabolizer no_sv,cnv3 cnv2 cnv2 5800.3 *2,*39,*34 . <42522613:C>G:42/83:0.51:missense_variant:low_impact:S486T>,<42523943:G>A:43/87:0.49:missense_variant:low_impact:R296C> . . 0.49 0.51 . 0.50 363170 g *1 *41 *1 *41,*2,*39,*34,*122,*131 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 2068.7 *41,*2,*39,*34,*122,*131 . <42523805:C>T:25/43:0.58:intron_variant:high_impact:splicing_defect> . <42522613:C>G:20/36:0.56:missense_variant:low_impact:S486T>,<42523943:G>A:16/40:0.40:missense_variant:low_impact:R296C> 0.51 0.49 . 0.58 363171 g *1 *2 *1 *2,*39,*127,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1927.7 *2,*39,*127,*34 . <42522613:C>G:17/42:0.40:missense_variant:low_impact:S486T>,<42523943:G>A:26/53:0.49:missense_variant:low_impact:R296C> . . 0.46 0.54 . 0.45 363172 g *4 *5 *4,*10,*39 *5,*10,*39 0.0 0.0 0.0 poor_metabolizer no_sv,cnv0 no_sv cnv0 1522.1 *5,*4,*10,*39 <42524947:C>T:17/19:0.89:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:19/19:1.00:missense_variant:high_impact:P34S> . 0.80 0.20 0.89 . 363173 g *10x2 *36+*10 *10x2 *36+*10 0.5 0.25 0.75 intermediate_metabolizer cnv2,gc_e9 cnv2 gc_e9 2731.3 *36,*83,*10,*39 <42526694:G>A:63/63:1.00:missense_variant:high_impact:P34S> <42525132:C>G:65/65:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:32/32:1.00:intron_variant:low_impact:no_effect>,<42526484:C>A:35/35:1.00:intron_variant:low_impact:no_effect>,<42526694:G>A:63/63:1.00:missense_variant:high_impact:P34S>,<42527793:C>T:69/69:1.00:upstream_gene_variant:low_impact:no_effect> . . . . . . 363174 g *1 *4 *1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2898.8 *4,*10,*39 . <42524947:C>T:19/46:0.41:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:17/33:0.52:missense_variant:high_impact:P34S> 0.60 0.40 . 0.41 363175 g *1 *4 *1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2259.1 *4,*10,*39 . <42524947:C>T:16/36:0.44:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:18/38:0.47:missense_variant:high_impact:P34S> 0.56 0.44 . 0.44 363176 g *2 *4 *2,*39,*34 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2290.5 *4,*10,*65,*2,*39,*34 <42522613:C>G:37/37:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:14/34:0.41:missense_variant:low_impact:R296C> <42524947:C>T:19/38:0.50:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:23/34:0.68:missense_variant:high_impact:P34S> 0.40 0.60 0.41 0.50 363177 g *5 *29 *5,*29,*2,*39,*34,*107 *29,*2,*39,*34,*107 0.0 0.5 0.5 intermediate_metabolizer no_sv,cnv0 cnv0 no_sv 2552.3 *5,*29,*2,*39,*34,*107 . <42522613:C>G:24/24:1.00:missense_variant:low_impact:S486T>,<42523610:C>T:20/21:0.95:missense_variant:moderate_impact:V338M>,<42523943:G>A:14/14:1.00:missense_variant:low_impact:R296C>,<42525134:C>T:15/15:1.00:missense_variant:moderate_impact:V136M> . . . . . . 363178 g *4 *35 *4,*10,*39 *35,*2,*39,*34 0.0 1.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1397.2 *4,*10,*65,*35,*2,*39,*34 <42524947:C>T:21/51:0.41:splice_acceptor_variant:high_impact:splicing_defect> <42522613:C>G:34/34:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:23/47:0.49:missense_variant:low_impact:R296C>,<42525132:C>G:35/35:1.00:synonymous_variant:low_impact:V136#>,<42526763:C>T:24/52:0.46:missense_variant:low_impact:V11M> <42526694:G>A:18/35:0.51:missense_variant:high_impact:P34S> . 0.56 0.44 0.41 0.48 363179 g *1 *14 *1 *14,*2,*39,*34 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 1449.7 *14,*2,*39,*34 . <42525035:C>T:43/85:0.51:missense_variant:high_impact:G169R> . <42522613:C>G:25/51:0.49:missense_variant:low_impact:S486T>,<42523943:G>A:22/53:0.42:missense_variant:low_impact:R296C> 0.55 0.45 . 0.51 363180 g *2 *3 *2,*39,*34 *3 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2304.1 *3,*2,*39,*34 <42522613:C>G:23/40:0.57:missense_variant:low_impact:S486T>,<42523943:G>A:22/50:0.44:missense_variant:low_impact:R296C> <42524243:CT>C:30/53:0.57:frameshift_variant:high_impact:frameshift> . . 0.48 0.52 0.51 0.57 363181 g *1 *46 *1 *46,*45,*2,*39,*34,*43 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1855.1 *46,*45,*2,*39,*34,*43 . <42522613:C>G:32/79:0.41:missense_variant:low_impact:S486T>,<42523943:G>A:54/86:0.63:missense_variant:low_impact:R296C>,<42525077:C>T:36/74:0.49:missense_variant:low_impact:E155K>,<42526717:C>T:25/57:0.44:missense_variant:low_impact:R26H> . . 0.52 0.48 . 0.49 363182 g *36+*10 *36+*10 *36+*10 *36+*10 0.25 0.25 0.5 intermediate_metabolizer gc_e9,gc_e9 gc_e9 gc_e9 2908.3 *36,*83,*69,*10,*41,*65,*2,*39,*34 <42525132:C>G:65/65:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:36/36:1.00:intron_variant:low_impact:no_effect>,<42526484:C>A:34/34:1.00:intron_variant:low_impact:no_effect> <42525132:C>G:65/65:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:36/36:1.00:intron_variant:low_impact:no_effect>,<42526484:C>A:34/34:1.00:intron_variant:low_impact:no_effect>,<42526694:G>A:65/89:0.73:missense_variant:high_impact:P34S>,<42527793:C>T:77/99:0.78:upstream_gene_variant:low_impact:no_effect> . . 0.27 0.73 . 0.75 363183 g *1 *2x2 *1 *2x2,*39,*34,*71 1.0 2.0 3.0 ultrarapid_metabolizer no_sv,cnv2 no_sv cnv2 4995.9 *2,*39,*34,*71 . <42522613:C>G:47/70:0.67:missense_variant:low_impact:S486T>,<42523943:G>A:48/87:0.55:missense_variant:low_impact:R296C> . . 0.32 0.68 . 0.61 363184 g *2x2 *6 *2x2,*39,*34 *6 2.0 0.0 2.0 normal_metabolizer no_sv,cnv2 cnv2 no_sv 2881.3 *6,*2,*39,*34 <42522613:C>G:72/100:0.72:missense_variant:low_impact:S486T>,<42523943:G>A:69/116:0.59:missense_variant:low_impact:R296C> <42525085:CA>C:34/112:0.30:frameshift_variant:high_impact:frameshift> . <42524817:C>T:33/140:0.24:missense_variant:moderate_impact:G212E> 0.61 0.39 0.66 0.30 363185 g *10 *45 *10,*39 *45,*2,*39,*34 0.25 1.0 1.25 normal_metabolizer no_sv,no_sv no_sv no_sv 2070.5 *10,*45,*2,*39,*34 <42526694:G>A:26/46:0.57:missense_variant:high_impact:P34S> <42522613:C>G:36/36:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:48/76:0.63:missense_variant:low_impact:R296C>,<42525077:C>T:37/64:0.58:missense_variant:low_impact:E155K> . . 0.48 0.52 0.57 0.60 363186 g *5 *127 *5 *127 0.0 unknown unknown unknown no_sv,cnv0 cnv0 no_sv 2340.6 *5,*127 . <42523528:C>T:7/22:0.32:missense_variant:moderate_impact:R365H>,<42523558:T>C:7/21:0.33:missense_variant:moderate_impact:Y355C> . . 0.60 0.40 . 0.33 363187 g *1 *5 *1 *5 1.0 0.0 1.0 intermediate_metabolizer no_sv,cnv0 no_sv cnv0 1827.8 *5 . . . . 0.32 0.68 . . 363188 g *2x2 *29 *2x2,*39,*34 *29,*2,*39,*34,*107 2.0 0.5 2.5 ultrarapid_metabolizer no_sv,cnv2 cnv2 no_sv 3349.7 *29,*2,*39,*34,*107 <42522613:C>G:46/46:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:68/68:1.00:missense_variant:low_impact:R296C> <42522613:C>G:46/46:1.00:missense_variant:low_impact:S486T>,<42523610:C>T:26/82:0.32:missense_variant:moderate_impact:V338M>,<42523943:G>A:68/68:1.00:missense_variant:low_impact:R296C>,<42525134:C>T:28/71:0.39:missense_variant:moderate_impact:V136M> . . 0.63 0.37 . 0.36 363189 g *2x2 *10 *2x2,*34 *10,*39 2.0 0.25 2.25 normal_metabolizer no_sv,cnv2 cnv2 no_sv 5629.7 *10,*65,*2,*39,*34 <42522613:C>G:39/39:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:58/95:0.61:missense_variant:low_impact:R296C> <42526694:G>A:21/70:0.30:missense_variant:high_impact:P34S> . . 0.62 0.38 0.61 0.30 363190 g *29 *29 *29,*2,*39,*34,*107 *29,*2,*39,*34,*107 0.5 0.5 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1282.1 *29,*2,*39,*34,*107 <42522613:C>G:38/38:1.00:missense_variant:low_impact:S486T>,<42523610:C>T:95/95:1.00:missense_variant:moderate_impact:V338M>,<42523943:G>A:51/51:1.00:missense_variant:low_impact:R296C>,<42525134:C>T:76/76:1.00:missense_variant:moderate_impact:V136M> <42522613:C>G:38/38:1.00:missense_variant:low_impact:S486T>,<42523610:C>T:95/95:1.00:missense_variant:moderate_impact:V338M>,<42523943:G>A:51/51:1.00:missense_variant:low_impact:R296C>,<42525134:C>T:76/76:1.00:missense_variant:moderate_impact:V136M> . . . . . . 363191 g *36+*10 *41 *36+*10,*39 *41,*2,*39,*34 0.25 0.5 0.75 intermediate_metabolizer no_sv,gc_e9 gc_e9 no_sv 2429.8 *36,*83,*69,*10,*41,*65,*2,*39,*34 <42525132:C>G:45/45:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:37/37:1.00:intron_variant:low_impact:no_effect>,<42526484:C>A:37/37:1.00:intron_variant:low_impact:no_effect>,<42526694:G>A:61/80:0.76:missense_variant:high_impact:P34S>,<42527793:C>T:26/49:0.53:upstream_gene_variant:low_impact:no_effect> <42523805:C>T:27/72:0.38:intron_variant:high_impact:splicing_defect> . <42522613:C>G:35/35:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:27/74:0.36:missense_variant:low_impact:R296C> 0.67 0.33 0.65 0.38 363192 g *1 *21 *1 *21,*2,*39,*34 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1576.9 *21,*2,*39,*34 . <42524213:C>CG:26/51:0.51:frameshift_variant:high_impact:frameshift> . <42522613:C>G:28/49:0.57:missense_variant:low_impact:S486T>,<42523943:G>A:23/40:0.57:missense_variant:low_impact:R296C>,<42525132:C>G:27/63:0.43:synonymous_variant:low_impact:V136#>,<42526580:C>G:21/54:0.39:intron_variant:low_impact:no_effect>,<42528382:G>C:20/49:0.41:upstream_gene_variant:low_impact:no_effect> 0.54 0.46 . 0.51 363193 g *2 *36+*10 *2,*39,*34 *36+*10,*39 1.0 0.25 1.25 normal_metabolizer no_sv,gc_e9 no_sv gc_e9 3554.8 *36,*83,*10,*65,*2,*39,*34 <42522613:C>G:37/37:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:26/83:0.31:missense_variant:low_impact:R296C> <42525132:C>G:83/83:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:41/41:1.00:intron_variant:low_impact:no_effect>,<42526484:C>A:42/42:1.00:intron_variant:low_impact:no_effect>,<42526694:G>A:72/101:0.71:missense_variant:high_impact:P34S>,<42527793:C>T:72/97:0.74:upstream_gene_variant:low_impact:no_effect> . . 0.35 0.65 0.31 0.73 363194 g *2 *2x2 *2,*39,*34 *2x2,*39,*34 1.0 2.0 3.0 ultrarapid_metabolizer no_sv,cnv2 no_sv cnv2 3456.9 *2,*39,*34 <42522613:C>G:66/66:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:60/60:1.00:missense_variant:low_impact:R296C> <42522613:C>G:66/66:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:60/60:1.00:missense_variant:low_impact:R296C> . . 0.69 0.31 . . 363195 g *5 *10 *5,*10,*39,*43 *10,*39,*43 0.0 0.25 0.25 intermediate_metabolizer no_sv,cnv0 cnv0 no_sv 1232.9 *5,*10,*39,*43 . <42526694:G>A:31/31:1.00:missense_variant:high_impact:P34S> . . . . . . 363196 g *4 *41 *4,*10,*39 *41,*2,*39,*34 0.0 0.5 0.5 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2225.6 *69,*4,*10,*41,*65,*2,*39,*34 <42524947:C>T:21/50:0.42:splice_acceptor_variant:high_impact:splicing_defect> <42523805:C>T:30/60:0.50:intron_variant:high_impact:splicing_defect> <42526694:G>A:25/49:0.51:missense_variant:high_impact:P34S> <42522613:C>G:37/37:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:35/65:0.54:missense_variant:low_impact:R296C> 0.48 0.52 0.42 0.50 363197 g *2 *4 *2,*39,*34 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 3419.2 *4,*10,*65,*2,*39,*34 <42522613:C>G:38/38:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:30/71:0.42:missense_variant:low_impact:R296C> <42524947:C>T:23/42:0.55:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:28/57:0.49:missense_variant:high_impact:P34S> 0.45 0.55 0.42 0.55 363198 g *1 *122 *1 *122,*131 1.0 unknown unknown unknown no_sv,no_sv no_sv no_sv 2390.5 *122,*131 . <42523514:C>T:4/54:0.07:missense_variant:moderate_impact:V370I> . . 0.68 0.32 . 0.07 363199 g *1 *35 *1 *35,*2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1940.8 *35,*2,*39,*34 . <42522613:C>G:26/49:0.53:missense_variant:low_impact:S486T>,<42523943:G>A:18/34:0.53:missense_variant:low_impact:R296C>,<42525132:C>G:23/48:0.48:synonymous_variant:low_impact:V136#>,<42526763:C>T:28/45:0.62:missense_variant:low_impact:V11M> . . 0.50 0.50 . 0.54 363200 g *7 *35 *7 *35,*2,*39,*34 0.0 1.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2656 *7,*35,*2,*39,*34 <42523858:T>G:25/45:0.56:missense_variant:high_impact:H324P> <42522613:C>G:20/37:0.54:missense_variant:low_impact:S486T>,<42523943:G>A:22/46:0.48:missense_variant:low_impact:R296C>,<42525132:C>G:26/43:0.60:synonymous_variant:low_impact:V136#>,<42526763:C>T:24/46:0.52:missense_variant:low_impact:V11M> . . 0.52 0.48 0.56 0.54 363201 g *1 *5 *1 *5 1.0 0.0 1.0 intermediate_metabolizer no_sv,cnv0 no_sv cnv0 3758.7 *5 . . . . 0.57 0.43 . . 363202 g *2 *17 *2,*39,*34 *17,*2,*39,*34 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 1546.7 *17,*2,*39,*34 <42522613:C>G:34/34:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:39/39:1.00:missense_variant:low_impact:R296C> <42525772:G>A:16/29:0.55:missense_variant:high_impact:T107I> . <42522613:C>G:34/34:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:39/39:1.00:missense_variant:low_impact:R296C> 0.37 0.63 . 0.55 363203 g *1x2 *13B *1x2 *13B 2.0 0.0 2.0 normal_metabolizer cnv2,gc_7to6_i1 cnv2 gc_7to6_i1 2742.3 *13B,*2,*39,*34 . . . . 0.53 0.47 . . 363686 g *1 *41 *1 *41,*2,*39,*34 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 4372.7 *41,*2,*39,*34 . <42523805:C>T:31/62:0.50:intron_variant:high_impact:splicing_defect> . <42522613:C>G:19/42:0.45:missense_variant:low_impact:S486T>,<42523943:G>A:37/71:0.52:missense_variant:low_impact:R296C> 0.50 0.50 . 0.50 363687 g *1 *28 *1 *28,*2,*39,*34 1.0 unknown unknown unknown no_sv,no_sv no_sv no_sv 1284 *28,*2,*39,*34 . <42522613:C>G:29/49:0.59:missense_variant:low_impact:S486T>,<42523943:G>A:27/70:0.39:missense_variant:low_impact:R296C>,<42525089:G>C:33/71:0.46:missense_variant:moderate_impact:Q151E>,<42526775:C>T:25/57:0.44:missense_variant:moderate_impact:V7M> . . 0.53 0.47 . 0.47 363688 g *1 *4N+*4 *1 *4N+*4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,gc_e9 no_sv gc_e9 2014.5 *36,*83,*4N,*4,*10,*39 . <42524947:C>T:50/81:0.62:splice_acceptor_variant:high_impact:splicing_defect> . . 0.29 0.71 . 0.62 363689 g *4 *9 *4,*10,*39 *9 0.0 0.5 0.5 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1921.3 *4,*10,*9,*39 <42524947:C>T:38/99:0.38:splice_acceptor_variant:high_impact:splicing_defect> <42524175:CCTT>C:24/57:0.42:inframe_deletion:moderate_impact:K281del> <42526694:G>A:31/57:0.54:missense_variant:high_impact:P34S> . 0.46 0.54 0.38 0.42 363690 g *1 *2 *1 *2,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 2444 *2,*34 . <42522613:C>G:33/54:0.61:missense_variant:low_impact:S486T>,<42523943:G>A:22/49:0.45:missense_variant:low_impact:R296C> . . 0.53 0.47 . 0.53 363691 g *1 *2 *1 *2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1990.8 *2,*39,*34 . <42522613:C>G:23/52:0.44:missense_variant:low_impact:S486T>,<42523943:G>A:28/59:0.47:missense_variant:low_impact:R296C> . . 0.56 0.44 . 0.46 363692 g *1 *1 *1 *1 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 3925.2 *1 . . . . 0.48 0.52 . . 363693 g *1 *4 *1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2277.7 *4,*10,*39 . <42524947:C>T:35/76:0.46:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:29/61:0.48:missense_variant:high_impact:P34S> 0.57 0.43 . 0.46 363694 g *10x2 *17 *10x2,*39 *17,*2,*39,*34 0.5 0.5 1.0 intermediate_metabolizer no_sv,cnv2 cnv2 no_sv 4664.6 *10,*17,*2,*39,*34 <42526694:G>A:64/88:0.73:missense_variant:high_impact:P34S> <42525772:G>A:35/79:0.44:missense_variant:high_impact:T107I> . <42522613:C>G:43/43:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:22/69:0.32:missense_variant:low_impact:R296C> 0.65 0.35 0.73 0.44 363695 g *1 *40 *1 *40,*17,*2,*39,*34 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2154.6 *40,*17,*2,*39,*34 . <42524929:T>TGGGGCGAAAGGGGCGAAA:23/52:0.44:inframe_insertion:high_impact:174_175insFRPFRP>,<42525772:G>A:35/56:0.62:missense_variant:high_impact:T107I> . <42522613:C>G:25/57:0.44:missense_variant:low_impact:S486T>,<42523943:G>A:21/54:0.39:missense_variant:low_impact:R296C>,<42526573:G>T:23/61:0.38:intron_variant:low_impact:no_effect>,<42526580:C>G:22/58:0.38:intron_variant:low_impact:no_effect>,<42527533:G>A:27/50:0.54:upstream_gene_variant:low_impact:no_effect> 0.57 0.43 . 0.53 363696 g *2 *5 *2,*39,*34 *5,*2,*39,*34 1.0 0.0 1.0 intermediate_metabolizer no_sv,cnv0 no_sv cnv0 1425.7 *5,*2,*39,*34 <42522613:C>G:34/34:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:36/36:1.00:missense_variant:low_impact:R296C> . . . . . . . 363697 g *1 *1 *1 *1 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1728.6 *1 . . . . 0.67 0.33 . . 363698 g *1 *2 *1 *2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1752.1 *2,*39,*34 . <42522613:C>G:20/40:0.50:missense_variant:low_impact:S486T>,<42523943:G>A:14/42:0.33:missense_variant:low_impact:R296C> . . 0.49 0.51 . 0.42 363699 g *4 *29 *4,*10,*39 *29,*2,*39,*34,*107 0.0 0.5 0.5 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1660.8 *4,*10,*29,*2,*39,*34,*107 <42524947:C>T:31/66:0.47:splice_acceptor_variant:high_impact:splicing_defect> <42522613:C>G:37/37:1.00:missense_variant:low_impact:S486T>,<42523610:C>T:28/62:0.45:missense_variant:moderate_impact:V338M>,<42523943:G>A:36/69:0.52:missense_variant:low_impact:R296C>,<42525134:C>T:33/72:0.46:missense_variant:moderate_impact:V136M> <42526694:G>A:27/50:0.54:missense_variant:high_impact:P34S> . 0.49 0.51 0.47 0.48 363700 g *7 *122 *7 *122 0.0 unknown unknown unknown no_sv,no_sv no_sv no_sv 1297.5 *7,*122 <42523858:T>G:35/69:0.51:missense_variant:high_impact:H324P> <42523514:C>T:7/68:0.10:missense_variant:moderate_impact:V370I> . . 0.64 0.36 0.51 0.10 363701 g *2 *2 *2,*39,*34 *2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 2717.2 *2,*39,*34 <42522613:C>G:31/31:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:34/34:1.00:missense_variant:low_impact:R296C> <42522613:C>G:31/31:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:34/34:1.00:missense_variant:low_impact:R296C> . . 0.40 0.60 . . 363702 g *1 *1 *1 *1 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1742.5 *1 . . . . 0.68 0.32 . . 363703 g *5 *131 *5 *131 0.0 unknown unknown unknown no_sv,cnv0 cnv0 no_sv 979.2 *5,*131 . <42524327:A>G:3/18:0.17:missense_variant:moderate_impact:L231P> . . 0.56 0.44 . 0.17 363704 g *1 *4 *1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1823.4 *4,*10,*39 . <42524947:C>T:39/78:0.50:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:19/40:0.47:missense_variant:high_impact:P34S> 0.47 0.53 . 0.50 363705 g *S1+*1 *4 *S1+*1,*4,*10,*39 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,gc_i1e9 gc_i1e9 no_sv 2754.6 *S1,*4,*10,*39 . <42524947:C>T:63/63:1.00:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:93/93:1.00:missense_variant:high_impact:P34S> 0.50 0.50 . . 363706 g *2 *2x2 *2,*39,*34 *2x2,*39,*34 1.0 2.0 3.0 ultrarapid_metabolizer no_sv,cnv2 no_sv cnv2 3223.3 *2,*39,*34 <42522613:C>G:35/35:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:41/41:1.00:missense_variant:low_impact:R296C> <42522613:C>G:35/35:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:41/41:1.00:missense_variant:low_impact:R296C> . . 0.36 0.64 . . 363707 g *1 *127 *1 *127 1.0 unknown unknown unknown no_sv,no_sv no_sv no_sv 1670.4 *127 . <42523528:C>T:9/69:0.13:missense_variant:moderate_impact:R365H>,<42523558:T>C:8/71:0.11:missense_variant:moderate_impact:Y355C> . . 0.57 0.43 . 0.12 363708 g *1 *17 *1 *17,*2,*39,*34 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 947.4 *17,*2,*39,*34 . <42525772:G>A:31/52:0.60:missense_variant:high_impact:T107I> . <42522613:C>G:27/55:0.49:missense_variant:low_impact:S486T>,<42523943:G>A:20/52:0.38:missense_variant:low_impact:R296C> 0.48 0.52 . 0.60 363709 g *1 *40 *1 *40,*17,*2,*39,*34,*122 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2337.5 *40,*17,*2,*39,*34,*122 . <42524929:T>TGGGGCGAAAGGGGCGAAA:34/60:0.57:inframe_insertion:high_impact:174_175insFRPFRP>,<42525772:G>A:23/56:0.41:missense_variant:high_impact:T107I> . <42522613:C>G:38/64:0.59:missense_variant:low_impact:S486T>,<42523943:G>A:39/64:0.61:missense_variant:low_impact:R296C>,<42526573:G>T:44/75:0.59:intron_variant:low_impact:no_effect>,<42526580:C>G:44/74:0.59:intron_variant:low_impact:no_effect>,<42527533:G>A:27/50:0.54:upstream_gene_variant:low_impact:no_effect> 0.52 0.48 . 0.49 363710 g *S1+*1 *3 *S1+*1,*4,*10,*39 *3 1.0 0.0 1.0 intermediate_metabolizer no_sv,gc_i1e9 gc_i1e9 no_sv 3367.5 *S1,*3,*4,*10,*39 . <42524243:CT>C:22/44:0.50:frameshift_variant:high_impact:frameshift> . . 0.51 0.49 . 0.50 363711 g *1 *15 *1 *15,*17,*2,*39,*34 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2231.8 *15,*17,*2,*39,*34 . <42526656:C>CA:19/49:0.39:frameshift_variant:high_impact:frameshift> . <42526562:C>G:33/52:0.63:intron_variant:low_impact:no_effect>,<42526571:G>C:33/54:0.61:intron_variant:low_impact:no_effect>,<42526573:G>T:33/54:0.61:intron_variant:low_impact:no_effect>,<42526580:C>G:32/51:0.63:intron_variant:low_impact:no_effect> 0.46 0.54 . 0.39 363712 g *1 *2 *1 *2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1959.9 *2,*39,*34 . <42522613:C>G:31/48:0.65:missense_variant:low_impact:S486T>,<42523943:G>A:25/55:0.45:missense_variant:low_impact:R296C> . . 0.53 0.46 . 0.55 363713 g *2 *17 *2,*39,*34 *17,*2,*39,*34 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 2777.7 *17,*2,*39,*34 <42522613:C>G:36/36:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:36/36:1.00:missense_variant:low_impact:R296C> <42525772:G>A:31/74:0.42:missense_variant:high_impact:T107I> . <42522613:C>G:36/36:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:36/36:1.00:missense_variant:low_impact:R296C> 0.53 0.47 . 0.42 363714 g *1 *29 *1 *29,*2,*39,*34,*107 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 950.1 *29,*2,*39,*34,*107 . <42522613:C>G:32/63:0.51:missense_variant:low_impact:S486T>,<42523610:C>T:34/67:0.51:missense_variant:moderate_impact:V338M>,<42523943:G>A:36/60:0.60:missense_variant:low_impact:R296C>,<42525134:C>T:26/63:0.41:missense_variant:moderate_impact:V136M> . . 0.49 0.51 . 0.51 363715 g *2 *41 *2,*39,*34 *41,*2,*39,*34 1.0 0.5 1.5 normal_metabolizer no_sv,no_sv no_sv no_sv 1280.3 *41,*2,*39,*34 <42522613:C>G:41/41:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:40/40:1.00:missense_variant:low_impact:R296C> <42523805:C>T:28/57:0.49:intron_variant:high_impact:splicing_defect> . <42522613:C>G:41/41:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:40/40:1.00:missense_variant:low_impact:R296C> 0.51 0.49 . 0.49 363716 g *1 *4 *1 *4,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1172 *4,*10,*39 . <42524947:C>T:33/85:0.39:splice_acceptor_variant:high_impact:splicing_defect> . <42526694:G>A:41/83:0.49:missense_variant:high_impact:P34S> 0.52 0.48 . 0.39 363717 g *S1+*1 *1x2 *S1+*1 *1x2 1.0 2.0 3.0 ultrarapid_metabolizer cnv2,gc_i1e9 gc_i1e9 cnv2 2956.4 *S1,*4,*10,*65,*2,*39,*34 . . . . 0.37 0.63 . . 363718 g *2 *36+*10 *2,*39,*34 *36+*10,*39 1.0 0.25 1.25 normal_metabolizer no_sv,gc_e9 no_sv gc_e9 2076.5 *36,*83,*10,*65,*2,*39,*34 <42522613:C>G:40/40:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:29/94:0.31:missense_variant:low_impact:R296C> <42525132:C>G:78/78:1.00:synonymous_variant:low_impact:V136#>,<42525952:A>C:43/43:1.00:intron_variant:low_impact:no_effect>,<42526484:C>A:34/34:1.00:intron_variant:low_impact:no_effect>,<42526694:G>A:44/66:0.67:missense_variant:high_impact:P34S>,<42527793:C>T:47/75:0.63:upstream_gene_variant:low_impact:no_effect> . . 0.32 0.68 0.31 0.65 363719 g *1 *40 *1 *40,*17,*2,*39,*34,*122 1.0 0.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 2124.6 *40,*17,*2,*39,*34,*122 . <42524929:T>TGGGGCGAAAGGGGCGAAA:38/69:0.55:inframe_insertion:high_impact:174_175insFRPFRP>,<42525772:G>A:41/67:0.61:missense_variant:high_impact:T107I> . <42522613:C>G:29/63:0.46:missense_variant:low_impact:S486T>,<42523943:G>A:32/67:0.48:missense_variant:low_impact:R296C>,<42526573:G>T:51/87:0.59:intron_variant:low_impact:no_effect>,<42526580:C>G:54/91:0.59:intron_variant:low_impact:no_effect>,<42527533:G>A:22/44:0.50:upstream_gene_variant:low_impact:no_effect> 0.51 0.49 . 0.58 363720 g *4 *40 *4,*10,*39 *40,*17,*2,*39,*34 0.0 0.0 0.0 poor_metabolizer no_sv,no_sv no_sv no_sv 865.1 *40,*4,*10,*17,*2,*39,*34 <42524947:C>T:31/59:0.53:splice_acceptor_variant:high_impact:splicing_defect> <42524929:T>TGGGGCGAAAGGGGCGAAA:31/57:0.54:inframe_insertion:high_impact:174_175insFRPFRP>,<42525772:G>A:27/46:0.59:missense_variant:high_impact:T107I> <42526694:G>A:15/47:0.32:missense_variant:high_impact:P34S> <42522613:C>G:48/48:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:36/67:0.54:missense_variant:low_impact:R296C>,<42526573:G>T:33/51:0.65:intron_variant:low_impact:no_effect>,<42526580:C>G:31/49:0.63:intron_variant:low_impact:no_effect>,<42527533:G>A:38/59:0.64:upstream_gene_variant:low_impact:no_effect> 0.46 0.54 0.53 0.57 363721 g *1 *2 *1 *2,*39,*34,*122 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1614.5 *2,*39,*34,*122 . <42522613:C>G:27/44:0.61:missense_variant:low_impact:S486T>,<42523943:G>A:31/56:0.55:missense_variant:low_impact:R296C> . . 0.53 0.47 . 0.58 363722 g *2 *2 *2,*39,*34 *2,*39,*34 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 2383.7 *2,*39,*34 <42522613:C>G:34/34:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:35/35:1.00:missense_variant:low_impact:R296C> <42522613:C>G:34/34:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:35/35:1.00:missense_variant:low_impact:R296C> . . . . . . 363723 g *1 *1 *1 *1 1.0 1.0 2.0 normal_metabolizer no_sv,no_sv no_sv no_sv 1456.3 *1 . . . . 0.48 0.52 . . 363724 g *1 *4x2 *1 *4x2,*10,*39 1.0 0.0 1.0 intermediate_metabolizer no_sv,cnv2 no_sv cnv2 1646.8 *4,*10,*39 . <42524947:C>T:72/101:0.71:splice_acceptor_variant:high_impact:splicing_defect> . . 0.33 0.67 . 0.71 363725 g *29 *106 *29,*2,*39,*34,*107 *106 0.5 unknown unknown unknown no_sv,no_sv no_sv no_sv 1989.6 *29,*2,*39,*34,*106,*107 <42522613:C>G:29/61:0.48:missense_variant:low_impact:S486T>,<42523610:C>T:41/83:0.49:missense_variant:moderate_impact:V338M>,<42523943:G>A:34/78:0.44:missense_variant:low_impact:R296C>,<42525134:C>T:36/79:0.46:missense_variant:moderate_impact:V136M> <42522916:C>T:18/34:0.53:missense_variant:moderate_impact:E418K> . . 0.49 0.51 0.47 0.53 363726 g *10 *41 *10,*39 *41,*2,*39,*34 0.25 0.5 0.75 intermediate_metabolizer no_sv,no_sv no_sv no_sv 3144.3 *69,*10,*41,*65,*2,*39,*34 <42526694:G>A:14/32:0.44:missense_variant:high_impact:P34S> <42523805:C>T:26/41:0.63:intron_variant:high_impact:splicing_defect> . <42522613:C>G:33/33:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:21/44:0.48:missense_variant:low_impact:R296C> 0.53 0.47 0.44 0.63 366874 g *4 *4x2 *4,*10,*39 *4x2,*10,*39 0.0 0.0 0.0 poor_metabolizer no_sv,cnv2 no_sv cnv2 2316.7 *4,*10,*39 <42524947:C>T:76/76:1.00:splice_acceptor_variant:high_impact:splicing_defect> <42524947:C>T:76/76:1.00:splice_acceptor_variant:high_impact:splicing_defect> <42526694:G>A:69/69:1.00:missense_variant:high_impact:P34S> . 0.26 0.74 . . 366882 g *4 *35 *4,*10,*39 *35,*2,*39,*34 0.0 1.0 1.0 intermediate_metabolizer no_sv,no_sv no_sv no_sv 1868.9 *4,*10,*65,*35,*2,*39,*34 <42524947:C>T:24/50:0.48:splice_acceptor_variant:high_impact:splicing_defect> <42522613:C>G:40/40:1.00:missense_variant:low_impact:S486T>,<42523943:G>A:17/34:0.50:missense_variant:low_impact:R296C>,<42525132:C>G:40/40:1.00:synonymous_variant:low_impact:V136#>,<42526763:C>T:29/42:0.69:missense_variant:low_impact:V11M> <42526694:G>A:17/41:0.41:missense_variant:high_impact:P34S> . 0.47 0.53 0.48 0.60